2-methyl-1,3-diphenylpropan-1-one

Base Information

• Chemical Name: 2-methyl-1,3-diphenylpropan-1-one
• CAS No.: 4842-43-7
• Molecular Formula: C16H16 O
• Molecular Weight: 224.302
• Mol file: 4842-43-7.mol

Synonyms:Propiophenone,2-methyl-3-phenyl- (6CI,7CI,8CI); 2-Methyl-1,3-diphenylpropan-1-one; NSC 167222

Chemical Property of 2-methyl-1,3-diphenylpropan-1-one

Chemical Property:

• Vapor Pressure: 2.28E-05mmHg at 25°C
• Boiling Point: 360.1°C at 760 mmHg
• Flash Point: 155.5°C
• Density: 1.042g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-1,3-diphenylpropan-1-one

There total 64 articles about 2-methyl-1,3-diphenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + dihydrochalcone (1083-30-3) → 2-methyl-1,3-diphenylpropan-1-one (4842-43-7)

Guidance literature:

With C₃₄H₂₇IrN₂P⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); caesium carbonate; at 65 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.201405990

Reference yield: 94.0%

1-phenyl-propan-1-one (93-55-0) + benzyl alcohol (100-51-6,185532-71-2) → 2-methyl-1,3-diphenylpropan-1-one (4842-43-7)

Guidance literature:

With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 1,3-bis((R)-1-(naphthalen-1-yl)ethyl)-4,5-dihydro-1H-imidazol-3-ium tetrafluoroborate; potassium tert-butylate; lithium tert-butoxide; In hexane; pentan-1-ol; at 100 ℃; for 24h;

DOI:10.1021/acscatal.6b01351

Reference yield: 88.0%

1-Phenyl-1-propanol (93-54-9) + benzyl alcohol (100-51-6,185532-71-2) → 2-methyl-1,3-diphenylpropan-1-one (4842-43-7)

Guidance literature:

With [Ni(dmpymt)₂]₆; potassium hydroxide; In toluene; at 100 ℃; for 24h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1039/C9OB00418A

upstream raw materials:

dihydrochalcone

1-phenyl-propan-1-one

methyl iodide

2-isopropenyl-4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine

Downstream raw materials:

3-oxy-2-methyl-1.3-diphenyl-pentane

4-phenylpivalophenone

2-benzyl-2-methyl-1-phenyl-pent-4-en-1-one

2-benzyl-2-methyl-3-phenyl-3-(phenylethynyl)oxirane