(+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one

Base Information

Chemical Name:(+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one
CAS No.:613233-57-1
Molecular Formula:C₂₄H₃₂O₅S
Molecular Weight:432.581
Hs Code.:

Synonyms:(+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one

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Chemical Property of (+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one

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Technology Process of (+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one

There total 8 articles about (+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 101020-89-7
dehydroqinghaosu

: 613233-75-3
p-(methylthio)phenethyl bromide

: 613233-73-1
(+)-octahydro-3,6α-dimethyl-3,12-epoxy-9α-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one

: 613233-57-1
(+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 9h; Heating;
DOI:10.1021/jm030181q

Reference yield:

: 613233-73-1
(+)-octahydro-3,6α-dimethyl-3,12-epoxy-9α-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one

: 613233-57-1
(+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 12h;
DOI:10.1021/jm030181q

Reference yield:

: 16188-55-9
2-(4-(methylthio)phenyl)acetic acid

: 613233-57-1
(+)-octahydro-3,6α-dimethyl-3,12-epoxy-9β-(3'-(p-methylthiophenyl)propyl)-12H-pyrano[4,3j]-1,2-benzodioxepin-10(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / BH₃ / tetrahydrofuran / 5 h / 0 °C

2: 92 percent / PPh₃; imidazole; bromine / diethyl ether; acetonitrile / 2 h / 20 °C

3: 38 percent / AIBN; tributyltin hydride / benzene / 9 h / Heating

4: DBU / tetrahydrofuran / 12 h

With 1H-imidazole; 2,2'-azobis(isobutyronitrile); borane; bromine; tri-n-butyl-tin hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; diethyl ether; acetonitrile; benzene; 3: radical-induced Michael addition;
DOI:10.1021/jm030181q