(Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: (Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER
• CAS No.: 86483-53-6
• Molecular Formula: C15H14 Cl2 F N O3
• Molecular Weight: 346.185
• Mol file: 86483-53-6.mol

Synonyms:(Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER

Chemical Property of (Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER

Chemical Property:

• Boiling Point: 477.9±45.0 °C(Predicted)
• PKA: 2.72±0.70(Predicted)
• PSA: 55.40000
• Density: 1.40±0.1 g/cm3(Predicted)
• LogP: 3.90510

Purity/Quality:

99% ^*data from raw suppliers

(Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER

There total 6 articles about (Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester (86483-52-5) + Cyclopropylamine (765-30-0) → 3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-ethylester (86483-53-6)

Guidance literature:

In ethanol; for 1h; Ambient temperature;

Reference yield:

N,N-dimethylaminoacrylic acid ethyl ester (16173-58-3) + 2,4-dichloro-5-fluorobenzoyl chloride (86393-34-2) + Cyclopropylamine (765-30-0) → 3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-ethylester (86483-53-6)

Guidance literature:

N,N-dimethylaminoacrylic acid ethyl ester; 2,4-dichloro-5-fluorobenzoyl chloride; With tributyl-amine; at 70 ℃; for 1h;

Cyclopropylamine; With carbon dioxide; at 15 ℃; under 1520.1 Torr; Temperature; Pressure; Reagent/catalyst;

Reference yield:

2,4-dichloro-5-fluorobenzoyl chloride (86393-34-2) → 3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-ethylester (86483-53-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Mg/ethanol, CCl₄ / ethanol; toluene / 1.) 0 to -5 deg C, 2.) 12 h, room temperature

2: p-toluenesulfonic acid / H₂O / 5 h / Heating

3: acetic anhydride / 2 h / Heating

4: 92 percent / ethanol / 1 h / Ambient temperature

With tetrachloromethane; ethanol; acetic anhydride; toluene-4-sulfonic acid; magnesium; In ethanol; water; toluene;

upstream raw materials:

2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester

Cyclopropylamine

ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate

2,4-dichloro-5-fluorobenzoyl chloride

Downstream raw materials:

ciprofloxacin

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

enrofloxacin

ciprofloxacin hydrochloride