1-phenyl-2,3-dihydro-1H-indene-1-carbonitrile

Base Information

• Chemical Name: 1-phenyl-2,3-dihydro-1H-indene-1-carbonitrile
• CAS No.: 145068-22-0
• Molecular Formula: C₁₆H₁₃N
• Molecular Weight: 219.286
• Mol file: 145068-22-0.mol

Synonyms:1-phenyl-2,3-dihydro-1H-indene-1-carbonitrile

Chemical Property of 1-phenyl-2,3-dihydro-1H-indene-1-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-phenyl-2,3-dihydro-1H-indene-1-carbonitrile

There total 5 articles about 1-phenyl-2,3-dihydro-1H-indene-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-phenyl-1H-indene (1961-97-3) + 1,4-dimethylcyclohexa-2,5-diene-1-carbonitrile → 1-phenyl-2,3-dihydro-1H-indene-1-carbonitrile (145068-22-0)

Guidance literature:

With bis(pentafluorophenyl)boron chloride; at 120 ℃; for 16h; Sealed tube;

DOI:10.1002/anie.201813853

Reference yield: 80.0%

fluorobenzene (462-06-6) + 1-cyanoindane (26452-97-1) → 1-phenyl-2,3-dihydro-1H-indene-1-carbonitrile (145068-22-0)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; toluene; for 21h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201302740

Reference yield:

1-Indanol (6351-10-6) → 1-phenyl-2,3-dihydro-1H-indene-1-carbonitrile (145068-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 9 h / 0 °C / Inert atmosphere; Reflux

2: dimethyl sulfoxide / 2 h / 140 °C / Inert atmosphere

3: potassium hexamethylsilazane / tetrahydrofuran; toluene / 21 h / Inert atmosphere; Reflux

With thionyl chloride; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1002/anie.201302740

upstream raw materials:

1-Indanol

1-chloroindane

fluorobenzene

1-cyanoindane

Downstream raw materials:

6-fluorochrysene

Refernces

• 1、 Fuchibe, Kohei,Mayumi, Yuka,Zhao, Nan,Watanabe, Shumpei,Yokota, Misaki,Ichikawa, Junji. "Domino synthesis of fluorine-substituted polycyclic aromatic hydrocarbons: 1,1-difluoroallenes as synthetic platforms". . p. 7825 - 7828. Retrieved 2013/08/23.