(R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(4'''-methoxybenzyloxy)acetamide

Base Information

Chemical Name:(R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(4'''-methoxybenzyloxy)acetamide
CAS No.:1234713-89-3
Molecular Formula:C₂₆H₃₁NO₄
Molecular Weight:421.536
Hs Code.:

Synonyms:(R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(4'''-methoxybenzyloxy)acetamide

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Chemical Property of (R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(4'''-methoxybenzyloxy)acetamide

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Technology Process of (R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(4'''-methoxybenzyloxy)acetamide

There total 2 articles about (R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(4'''-methoxybenzyloxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2-(4'-methoxybenzyloxy)acetyl chloride

: 1234713-89-3
(R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(4'''-methoxybenzyloxy)acetamide

Guidance literature:: With sodium hydroxide; In dichloromethane; water; at 0 - 20 ℃; for 48h;
DOI:10.1016/j.tet.2010.03.105

Reference yield: 24.0%

: 1234713-90-6
(R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-bromoacetamide

: 105-13-5
4-Methoxybenzyl alcohol

: 1234713-91-7
(R)-N-1'-(1''-naphthyl)ethyl (ξ)-2-(4'''-methoxybenzyloxy)-2-tert-butoxyacetamide

: 1234713-89-3
(R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(4'''-methoxybenzyloxy)acetamide

Guidance literature:: 4-Methoxybenzyl alcohol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.16667h; Inert atmosphere;

(R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-bromoacetamide; In tetrahydrofuran; at 20 ℃; for 6h;

With ammonium chloride; In tetrahydrofuran; water; optical yield given as %de;
DOI:10.1016/j.tet.2010.03.105

Reference yield: 87.0%

: 628-17-1
amyl iodide

: 1234713-89-3
(R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(4'''-methoxybenzyloxy)acetamide

: 1234714-11-4
(R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (S)-2-(4'''-methoxybenzyloxy)heptanamide

Guidance literature:: (R)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(4'''-methoxybenzyloxy)acetamide; With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

amyl iodide; In tetrahydrofuran; at -78 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tet.2010.03.105