6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid

Base Information

Chemical Name:6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid
CAS No.:865300-81-8
Molecular Formula:C₁₆H₁₂ClFN₂O₅
Molecular Weight:366.733
Hs Code.:

Synonyms:6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid

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Chemical Property of 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid

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Technology Process of 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid

There total 9 articles about 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 865300-86-3
ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

: 865300-81-8
6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; water; at 50 - 53 ℃; for 1.75h; Large scale;
DOI:10.1021/acs.joc.6b01229

Reference yield:

: 1080623-42-2
ethyl 2-amino-2-(1-(3-chloro-4-fluorobenzyl)-2-oxo-3-(phenylsulfinyl)piperidin-4-yl)acetate

: 865300-81-8
6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / toluene; Isopropyl acetate / 0.5 h / 90 °C / Large scale

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 3.5 °C / Large scale

2.2: 16 h / 20 °C / Large scale

3.1: sodium hydroxide / water; tetrahydrofuran; ethanol / 1.75 h / 50 - 53 °C / Large scale

3.2: 12 h / 20 °C / Large scale

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; Isopropyl acetate; water; toluene;

Reference yield:

: 1-(3-chloro-4-fluorobenzyl)-3-(phenylsulfinyl)-5,6-dihydropyridin-2(1H)-on

: 865300-81-8
6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium 2-methylpropan-2-olate / tetrahydrofuran / 1 h / 0 - 15 °C / Large scale

2.1: N-ethyl-N,N-diisopropylamine / toluene; Isopropyl acetate / 0.5 h / 90 °C / Large scale

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 3.5 °C / Large scale

3.2: 16 h / 20 °C / Large scale

4.1: sodium hydroxide / water; tetrahydrofuran; ethanol / 1.75 h / 50 - 53 °C / Large scale

4.2: 12 h / 20 °C / Large scale

With lithium 2-methylpropan-2-olate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; Isopropyl acetate; water; toluene;