6-nitro-2-phenyl quinoline-4-carboxylic acid

Base Information

• Chemical Name: 6-nitro-2-phenyl quinoline-4-carboxylic acid
• CAS No.: 871883-56-6
• Molecular Formula: C₁₆H₁₀N₂O₄
• Molecular Weight: 294.266
• Mol file: 871883-56-6.mol

Synonyms:6-nitro-2-phenyl quinoline-4-carboxylic acid

Chemical Property of 6-nitro-2-phenyl quinoline-4-carboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-nitro-2-phenyl quinoline-4-carboxylic acid

There total 3 articles about 6-nitro-2-phenyl quinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

benzaldehyde (100-52-7) + 2-oxo-propionic acid (127-17-3) + 4-nitro-aniline (100-01-6,104810-17-5) → 6-nitro-2-phenyl quinoline-4-carboxylic acid (871883-56-6)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; for 0.05h; Microwave irradiation; Green chemistry;

DOI:10.1002/jhet.3848

Reference yield: 56.0%

5-nitroisatin (611-09-6) + acetophenone (98-86-2) → 6-nitro-2-phenyl quinoline-4-carboxylic acid (871883-56-6)

Guidance literature:

With potassium hydroxide; In water; Reflux;

DOI:10.1155/2019/2859637

Reference yield:

→ 6-nitro-2-phenyl quinoline-4-carboxylic acid (871883-56-6)

Guidance literature:

upstream raw materials:

benzaldehyde

2-oxo-propionic acid

4-nitro-aniline

5-nitroisatin

Downstream raw materials:

ethyl 6-nitro-2-phenylquinoline-4-carboxylate

Refernces

• 1、 Patel, Dhaval B.,Patel, Hitesh D.,Rajani, Dhanji P.,Rajani, Smita D.. "A green synthesis of quinoline-4-carboxylic derivatives using p-toluenesulfonic acid as an efficient organocatalyst under microwave irradiation and their docking, molecular dynamics, ADME-Tox and biological evaluation". . . Retrieved 2020/02/27.
• 2、 Saeed,Elhadi. "Synthesis of some 2-aryl- and 2,3-diaryl-quinolin-4-carboxylic acid derivatives". experimental part. p. 1435 - 1443. Retrieved 2011/06/20.