ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate

Base Information

Chemical Name:ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate
CAS No.:1373613-94-5
Molecular Formula:C₁₈H₂₄N₂O₅
Molecular Weight:348.399
Hs Code.:

Synonyms:ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate

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Chemical Property of ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate

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Technology Process of ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate

There total 4 articles about ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1373613-93-4
3-{N-benzyloxycarbonyl-N-(ethoxycarbonylmethyl)amino}propionic acid

: 765-30-0
Cyclopropylamine

: 1373613-94-5
ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 2-methyltetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h; Solvent; Reagent/catalyst; Temperature; Time;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1373613-94-5
ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / water; isopropyl alcohol / 30 - 64 °C

1.2: 2 h / 25 - 36 °C

2.1: trifluoroacetic acid / dichloromethane / 30 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 2-methyltetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 2-methyltetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1373613-92-3
tert-butyl 3-{N-benzyloxycarbonyl-N-(ethoxycarbonylmethyl)amino}propionate

: 1373613-94-5
ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 30 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 2-methyltetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In 2-methyltetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;