3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione

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Chemical Name:3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione
CAS No.:626603-93-8
Molecular Formula:C₂₀H₁₆ClN₃O₃
Molecular Weight:381.818
Hs Code.:

Synonyms:3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione

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Chemical Property of 3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione

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Technology Process of 3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione

There total 5 articles about 3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 7647-01-0,15364-23-5
hydrogenchloride

: 10268-06-1
2-(2-chlorophenyl)acetamide

: 626604-78-2
{1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-oxo-acetic acid methyl ester

: 626603-93-8
3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione

Guidance literature:: 2-(2-chlorophenyl)acetamide; {1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-oxo-acetic acid methyl ester; With potassium tert-butylate; In tetrahydrofuran; for 0.5h; Cooling with ice;

In tetrahydrofuran; at 20 ℃; for 0.5h;

hydrogenchloride; for 0.0833333h;

Reference yield:

: 271-63-6
7-Azaindole

: 626603-93-8
3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: EtMgBr / tetrahydrofuran / -65 °C

1.2: 24 percent / tetrahydrofuran / -78 °C

2.1: 44 percent / Cs₂CO₃ / dimethylformamide / 50 °C

3.1: t-BuOK / tetrahydrofuran / 0 °C

4.1: aq. HCl

With hydrogenchloride; ethylmagnesium bromide; potassium tert-butylate; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.03.090

Reference yield:

: 357263-49-1
methyl α-oxo-1H-pyrrolo[2,3-b]pyridine-3-acetate

: 626603-93-8
3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 44 percent / Cs₂CO₃ / dimethylformamide / 50 °C

2: t-BuOK / tetrahydrofuran / 0 °C

3: aq. HCl

With hydrogenchloride; potassium tert-butylate; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.03.090