4-phenoxypropiophenone

Base Information

• Chemical Name: 4-phenoxypropiophenone
• CAS No.: 889-26-9
• Molecular Formula: C15H14 O2
• Molecular Weight: 226.275
• Hs Code.: 2914509090
• Mol file: 889-26-9.mol

Synonyms:Propiophenone,4'-phenoxy- (7CI,8CI); 1-(4-Phenoxyphenyl)-1-propanone; 4'-Phenoxypropiophenone

Chemical Property of 4-phenoxypropiophenone

Chemical Property:

• PSA: 26.30000
• LogP: 4.07160

Purity/Quality:

98% ^*data from raw suppliers

1-(4-Phenoxyphenyl)propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-phenoxypropiophenone

There total 8 articles about 4-phenoxypropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-(4-fluorophenyl)propanol (701-47-3,166371-89-7) + phenol (108-95-2,27073-41-2) → 1-(4-phenoxyphenyl)propan-1-one (889-26-9)

Guidance literature:

With carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); potassium carbonate; 1,2-bis-(diphenylphosphino)ethane; In dimethyl sulfoxide; acetone; at 130 ℃; for 24h; Microwave irradiation; Sealed tube;

DOI:10.1021/acs.orglett.7b03441

Reference yield: 61.0%

1-(4-fluorophenyl)allyl alcohol (5724-03-8) + phenol (108-95-2,27073-41-2) → 1-(4-phenoxyphenyl)propan-1-one (889-26-9)

Guidance literature:

With carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether; In dimethyl sulfoxide; at 115 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201200879

Reference yield: 60.0%

1-(4-fluorophenyl)propan-1-one (456-03-1) + phenol (108-95-2,27073-41-2) → 1-(4-phenoxyphenyl)propan-1-one (889-26-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 6h;

upstream raw materials:

diphenylether

propionyl chloride

propionic acid anhydride

1-(4-fluorophenyl)propan-1-one

Downstream raw materials:

1-phenoxy-4-(prop-1-en-1-yl)benzene

1-(4-phenoxyphenyl)propan-1-amine

2-{1-(4-Phenoxyphenyl)propan-1-ylidene}-5-methyl-1,3,5-dithiazine

2-bromo-4'-phenoxyfuropiophenone

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS". Paragraph 0332-0333. . Retrieved 2020/07/16.
• 2、 Watson, Andrew J. A.,Atkinson, Benjamin N.,Maxwell, Aoife C.,Williams, Jonathan M. J.. "Ruthenium-catalyzed remote electronic activation of aromatic C-F bonds". supporting information. p. 734 - 740. Retrieved 2013/04/10.