3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

Base Information

Chemical Name:3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole
CAS No.:1239956-62-7
Molecular Formula:C₂₆H₂₄ClF₂N₃O₂S
Molecular Weight:516.011
Hs Code.:

Synonyms:3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

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Chemical Property of 3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

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Technology Process of 3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

There total 6 articles about 3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1239964-46-5
3-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione

: 55117-15-2
2-chloro-6 fluorobenzyl chloride

: 1239956-62-7
3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

Guidance literature:: 3-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione; With potassium carbonate; In acetone; at 20 ℃; for 0.5h;

2-chloro-6 fluorobenzyl chloride; In acetone; for 2h; Reflux;

Reference yield:

: 23023-16-7
2‐(3,4‐dimethoxyphenyl)‐2‐methylpropionitrile

: 1239956-62-7
3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; water / 7 h / Reflux

2.1: sulfuric acid / 12 h / Reflux

3.1: hydrazine hydrate / methanol / 18 h / 110 °C / sealed tube

4.1: ethanol / 2 h / Reflux

5.1: sodium hydroxide / Reflux

5.2: 20 °C / pH 5

6.1: potassium carbonate / acetone / 0.5 h / 20 °C

6.2: 2 h / Reflux

With sulfuric acid; water; potassium carbonate; hydrazine hydrate; sodium hydroxide; sulfuric acid; In methanol; ethanol; acetone;

Reference yield:

: 59212-11-2
2-(3,4-dimethoxyphenyl)-2-methylpropanoic acid

: 1239956-62-7
3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 12 h / Reflux

2.1: hydrazine hydrate / methanol / 18 h / 110 °C / sealed tube

3.1: ethanol / 2 h / Reflux

4.1: sodium hydroxide / Reflux

4.2: 20 °C / pH 5

5.1: potassium carbonate / acetone / 0.5 h / 20 °C

5.2: 2 h / Reflux

With potassium carbonate; hydrazine hydrate; sodium hydroxide; sulfuric acid; In methanol; ethanol; acetone;