Technology Process of 3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole
There total 6 articles about 3-(2-chloro-6-fluorobenzylthio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-1,2,4-triazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione;
With
potassium carbonate;
In
acetone;
at 20 ℃;
for 0.5h;
2-chloro-6 fluorobenzyl chloride;
In
acetone;
for 2h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid; water / 7 h / Reflux
2.1: sulfuric acid / 12 h / Reflux
3.1: hydrazine hydrate / methanol / 18 h / 110 °C / sealed tube
4.1: ethanol / 2 h / Reflux
5.1: sodium hydroxide / Reflux
5.2: 20 °C / pH 5
6.1: potassium carbonate / acetone / 0.5 h / 20 °C
6.2: 2 h / Reflux
With
sulfuric acid; water; potassium carbonate; hydrazine hydrate; sodium hydroxide;
sulfuric acid;
In
methanol; ethanol; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid / 12 h / Reflux
2.1: hydrazine hydrate / methanol / 18 h / 110 °C / sealed tube
3.1: ethanol / 2 h / Reflux
4.1: sodium hydroxide / Reflux
4.2: 20 °C / pH 5
5.1: potassium carbonate / acetone / 0.5 h / 20 °C
5.2: 2 h / Reflux
With
potassium carbonate; hydrazine hydrate; sodium hydroxide;
sulfuric acid;
In
methanol; ethanol; acetone;
