N-methoxy-N-methylcycloheptanecarboxamide

Base Information

• Chemical Name: N-methoxy-N-methylcycloheptanecarboxamide
• CAS No.: 253429-08-2
• Molecular Formula: C₁₀H₁₉NO₂
• Molecular Weight: 185.266
• Hs Code.: 2922500090
• Mol file: 253429-08-2.mol

Synonyms:N-methoxy-N-methylcycloheptanecarboxamide

Chemical Property of N-methoxy-N-methylcycloheptanecarboxamide

Chemical Property:

• Boiling Point: 244.6±23.0 °C(Predicted)
• Density: 0.998±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

N-methoxy-N-methylcycloheptanecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-methoxy-N-methylcycloheptanecarboxamide

There total 4 articles about N-methoxy-N-methylcycloheptanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.44%

cycloheptanoic acid (1460-16-8) + N,0-dimethylhydroxylamine (1117-97-1) → N-methoxy-N-methylcycloheptanecarboxamide (253429-08-2)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

Reference yield:

cycloheptanecarbonyl chloride (6557-86-4) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methylcycloheptanecarboxamide (253429-08-2)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

cycloheptanoic acid (1460-16-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methylcycloheptanecarboxamide (253429-08-2)

Guidance literature:

cycloheptanoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere; Sealed tube;

N,O-dimethylhydroxylamine*hydrochloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.0c03737

upstream raw materials:

cycloheptanecarbonyl chloride

N,O-dimethylhydroxylamine*hydrochloride

methyl cycloheptanecarboxylate

N,0-dimethylhydroxylamine

Refernces

• 1、 -. "TRICYCLIC COMPOUND SERVING AS IMMUNOMODULATOR". Paragraph 0613-0614. . Retrieved 2019/01/04.
• 2、 -. "Piperidine derivatives as reuptake inhibitors". Page column 34-35. . Retrieved 2010/02/09.