(+/-)-O-acetyl-p-nitromandelonitrile

Base Information

• Chemical Name: (+/-)-O-acetyl-p-nitromandelonitrile
• CAS No.: 134895-40-2
• Molecular Formula: C₁₀H₈N₂O₄
• Molecular Weight: 220.185
• Mol file: 134895-40-2.mol

Synonyms:(+/-)-O-acetyl-p-nitromandelonitrile

Chemical Property of (+/-)-O-acetyl-p-nitromandelonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-O-acetyl-p-nitromandelonitrile

There total 6 articles about (+/-)-O-acetyl-p-nitromandelonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trimethylsilyl cyanide (7677-24-9) + 4-nitrobenzylidene diacetate (2929-91-1) → (+/-)-O-acetyl-p-nitromandelonitrile (134895-40-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/ol005535b

Reference yield: 94.0%

2-(4-nitrophenyl)-2-[(trimethylsilyl)oxy]acetonitrile (71189-80-5) + acetic anhydride (108-24-7) → (+/-)-O-acetyl-p-nitromandelonitrile (134895-40-2)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(02)01200-5

Reference yield: 87.0%

[bis(acetoxy)iodo]benzene (3240-34-4) + 4-Nitrophenylacetonitrile (555-21-5,34512-13-5,174848-08-9) → (+/-)-O-acetyl-p-nitromandelonitrile (134895-40-2)

Guidance literature:

With dibenzoyl peroxide; In acetonitrile; for 3h; Heating;

DOI:10.1080/00397919108016779

upstream raw materials:

[bis(acetoxy)iodo]benzene

4-Nitrophenylacetonitrile

trimethylsilyl cyanide

4-nitrobenzylidene diacetate