5-(dimethylamino)-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}-1-naphthalenesulfonamide

Base Information

• Chemical Name: 5-(dimethylamino)-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}-1-naphthalenesulfonamide
• CAS No.: 198063-15-9
• Molecular Formula: C₁₈H₂₆N₂O₅S
• Molecular Weight: 382.481
• Mol file: 198063-15-9.mol

Synonyms:5-(dimethylamino)-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}-1-naphthalenesulfonamide

Chemical Property of 5-(dimethylamino)-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}-1-naphthalenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(dimethylamino)-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}-1-naphthalenesulfonamide

There total 2 articles about 5-(dimethylamino)-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}-1-naphthalenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) + 5-(dimethylamino)naphth-1-ylsulfonyl chloride (605-65-2) → 5-(dimethylamino)-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}-1-naphthalenesulfonamide (198063-15-9)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

DOI:10.1080/00304940109356618

Reference yield:

2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7) → 5-(dimethylamino)-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}-1-naphthalenesulfonamide (198063-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / H₂ / Pd/C / CHCl₃; methanol / 40 h / 20 °C / 1292.87 - 2585.74 Torr

2: 83 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 1.5 h / 20 °C

With hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water;

DOI:10.1080/00304940109356618

Reference yield: 66.0%

p-toluenesulfonyl chloride (98-59-9) + 5-(dimethylamino)-N-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}-1-naphthalenesulfonamide (198063-15-9) → Toluene-4-sulfonic acid 2-{2-[2-(5-dimethylamino-naphthalene-1-sulfonylamino)-ethoxy]-ethoxy}-ethyl ester (198063-16-0)

Guidance literature:

With pyridine; for 38h;

DOI:10.1039/a701142c

upstream raw materials:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

5-(dimethylamino)naphth-1-ylsulfonyl chloride

2-[2-(2-azidoethoxy)ethoxy]ethanol

Downstream raw materials:

Toluene-4-sulfonic acid 2-{2-[2-(5-dimethylamino-naphthalene-1-sulfonylamino)-ethoxy]-ethoxy}-ethyl ester