4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile

Base Information

Chemical Name:4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile
CAS No.:1355656-87-9
Molecular Formula:C₂₁H₁₈ClN₃O₃
Molecular Weight:395.845
Hs Code.:

Synonyms:4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile

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Chemical Property of 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile

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Technology Process of 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile

There total 5 articles about 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1355656-84-6
3-bromo-4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]benzonitrile

: 163105-90-6
2-methoxypyridin-3-yl-boronic acid

: 1355656-87-9
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1344997-94-9
3-chloro-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1355656-87-9
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: peracetic acid; acetic acid / water / 4 h / 0 - 20 °C

2: potassium carbonate / dimethyl sulfoxide / 4 h / 50 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With peracetic acid; sodium carbonate; potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; dimethyl sulfoxide;

Reference yield:

: 282723-22-2
2-Isopropoxy-3-chloropyridine

: 1355656-87-9
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 4,4'-di-tert-butyl-2,2'-bipyridine / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 18 h / Inert atmosphere

2: peracetic acid; acetic acid / water / 4 h / 0 - 20 °C

3: potassium carbonate / dimethyl sulfoxide / 4 h / 50 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With peracetic acid; sodium carbonate; potassium carbonate; acetic acid; 4,4'-di-tert-butyl-2,2'-bipyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In 1,4-dioxane; n-heptane; water; dimethyl sulfoxide;