4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester

Base Information

Chemical Name:4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester
CAS No.:103772-83-4
Molecular Formula:C₂₁H₂₃Cl₂NO₆
Molecular Weight:456.323
Hs Code.:

Synonyms:4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester

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Chemical Property of 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester

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Technology Process of 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester

There total 3 articles about 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 105-45-3
acetoacetic acid methyl ester

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 86780-81-6
3-amino-2-crotonic acid 2,2-ethylenedioxy propyl ester

: 103772-83-4
4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester

Guidance literature:: In ethanol; for 8h; Heating;
DOI:10.1248/cpb.34.1589

Reference yield:

: 10004-17-8
(2-methyl-[1,3]dioxolan-2-yl)-methanol

: 103772-83-4
4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / 60percent NaH in oil / 2 h / 70 - 80 °C

2: 84 percent / NH₃ / methanol / 2.5 h / 0 - 5 °C

3: 27 percent / ethanol / 8 h / Heating

With ammonia; sodium hydride; In methanol; ethanol;
DOI:10.1248/cpb.34.1589

Reference yield:

: 86780-80-5
2,2-ethylenedioxypropyl acetoacetate

: 103772-83-4
4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / NH₃ / methanol / 2.5 h / 0 - 5 °C

2: 27 percent / ethanol / 8 h / Heating

With ammonia; In methanol; ethanol;
DOI:10.1248/cpb.34.1589