Technology Process of 4-(2-(2,4-dimethylphenylthio)phenyl)thiomorpholine
There total 5 articles about 4-(2-(2,4-dimethylphenylthio)phenyl)thiomorpholine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2-(2,4-dimethylphenylthio)phenyl)thiomorpholine-3,5-dione;
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
for 1.5h;
Inert atmosphere;
Reflux;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
for 0.166667h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C
2.1: triethylamine; dmap / dichloromethane / 0.58 h / 80 °C / Inert atmosphere; Microwave irradiation
2.2: 18 h / 20 °C
3.1: dimethylsulfide borane complex / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux
3.2: 0.17 h
With
dmap; dimethylsulfide borane complex; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 72 h / Reflux
2.1: tris-(dibenzylideneacetone)dipalladium(0); bis[2-(diphenylphosphino)phenyl] ether; potassium tert-butylate / toluene / 21 h / 100 °C
3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C
4.1: triethylamine; dmap / dichloromethane / 0.58 h / 80 °C / Inert atmosphere; Microwave irradiation
4.2: 18 h / 20 °C
5.1: dimethylsulfide borane complex / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux
5.2: 0.17 h
With
dmap; tris-(dibenzylideneacetone)dipalladium(0); dimethylsulfide borane complex; potassium tert-butylate; triethylamine; trifluoroacetic acid; bis[2-(diphenylphosphino)phenyl] ether;
In
tetrahydrofuran; dichloromethane; toluene;
