2,4-DIFLUOROANILINE

Base Information

• Chemical Name: 2,4-DIFLUOROANILINE
• CAS No.: 76563-56-9
• Molecular Formula: C₆H₅F₂N
• Molecular Weight: 129.109
• Mol file: 76563-56-9.mol

Synonyms:2,4-Difluoroanilineradical cation

Chemical Property of 2,4-DIFLUOROANILINE

Chemical Property:

• PSA: 26.02000
• LogP: 2.12820

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIFLUOROANILINE

There total 25 articles about 2,4-DIFLUOROANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Chloro-3,4-difluoroaniline (36556-48-6) + 2,4-difluoro-3-chloro-aniline (2613-34-5) → 2,4-difluorophenylamine (367-25-9,76563-56-9)

Guidance literature:

With sodium hydroxide; palladium; In hydrogenchloride; methanol; water;

Reference yield: 99.0%

2,4-Difluoronitrobenzene (446-35-5) → 2,4-difluorophenylamine (367-25-9,76563-56-9)

Guidance literature:

With hydrazine hydrate; at 90 ℃; for 1.33333h; chemoselective reaction;

DOI:10.1080/00397911.2010.523159

Reference yield: 80.0%

5-chloro-2,4-difluoronitrobenzene (1481-68-1) → 2,4-difluorophenylamine (367-25-9,76563-56-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 80 ℃; for 6h; under 5250.4 Torr;

DOI:10.1080/00397919408011503

upstream raw materials:

2,4-Difluoronitrobenzene

1-chloro-3,5-difluorobenzene

5-chloro-2,4-difluoronitrobenzene

N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)-3-pyridinecarboxamide

Downstream raw materials:

hydroxyimino-acetic acid-(2,4-difluoro-anilide)

N-(4-chloro-phenyl)-N'-(2,4-difluoro-phenyl)-urea

1-(4-bromophenyl)-3-(2,4-difluorophenyl)thiourea

bis(2,4-difluorophenylsulfonyl)methane

Refernces

• 1、 Lu, Xionggang,Ren, Jiaan,Sheng, Yao,Wang, Xueguang,Wu, Baoqin,Zou, Xiujing. "Efficient and recyclable bimetallic Co–Cu catalysts for selective hydrogenation of halogenated nitroarenes". . . Retrieved 2021/12/20.
• 2、 -. "Efficient synthesis method of meta-fluoranisole (by machine translation)". Paragraph 0026; 0033; 0036; 0043; 0046; 0053; 0056; 0063. . Retrieved 2020/06/05.