7-(4-methylpiperazin-1-yl)-6-nitro-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazoline

Base Information

Chemical Name:7-(4-methylpiperazin-1-yl)-6-nitro-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazoline
CAS No.:1418149-57-1
Molecular Formula:C₂₀H₁₈N₈O₃S
Molecular Weight:450.481
Hs Code.:

Synonyms:7-(4-methylpiperazin-1-yl)-6-nitro-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazoline

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Chemical Property of 7-(4-methylpiperazin-1-yl)-6-nitro-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazoline

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Technology Process of 7-(4-methylpiperazin-1-yl)-6-nitro-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazoline

There total 1 articles about 7-(4-methylpiperazin-1-yl)-6-nitro-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1418149-57-1
7-(4-methylpiperazin-1-yl)-6-nitro-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus pentachloride / 3 h / 160 °C

2.1: potassium carbonate / isopropyl alcohol / 7 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Reflux

3.2: 5 h / Reflux

With phosphorus pentachloride; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1007/s00044-012-0408-0

Reference yield:

: 1418149-57-1
7-(4-methylpiperazin-1-yl)-6-nitro-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazoline

: 1418149-87-7
1-(cyclohexyl)-3-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; iron / water / 5 h / 10 - 20 °C

2: N,N-dimethyl-formamide / 12 h / 20 °C

With iron; acetic acid; In water; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0408-0

Reference yield:

: 1418149-57-1
7-(4-methylpiperazin-1-yl)-6-nitro-4-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)sulfanyl]quinazoline

: 1418149-88-8
1-(7-(4-methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)quinazolin-6-yl)-3-phenyl thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; iron / water / 5 h / 10 - 20 °C

2: N,N-dimethyl-formamide / 12 h / 20 °C

With iron; acetic acid; In water; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0408-0