Technology Process of Boronic acid, [4-[[(1,1-dimethylethyl)dimethylsilyl]thio]phenyl]-
There total 4 articles about Boronic acid, [4-[[(1,1-dimethylethyl)dimethylsilyl]thio]phenyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4-bromophenylsulfanyl)-tert-butyldimethylsilane;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.25h;
With
Triisopropyl borate;
In
tetrahydrofuran;
at -78 - -20 ℃;
for 4h;
DOI:10.1016/S0022-328X(99)00086-8
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 92 percent / sodium hydride in oil / tetrahydrofuran / 14 h / 20 °C
2.1: n-butyl lithium / tetrahydrofuran; hexane / 0.25 h / -78 °C
2.2: 77 percent / tri-isopropyl borate / tetrahydrofuran / 4 h / -78 - -20 °C
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran; hexane;
1.1: Alkylation / 2.1: Metallation / 2.2: Acylation;
DOI:10.1016/S0022-328X(99)00086-8
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 92 percent / sodium hydride in oil / tetrahydrofuran / 14 h / 20 °C
2.1: n-butyl lithium / tetrahydrofuran; hexane / 0.25 h / -78 °C
2.2: 77 percent / tri-isopropyl borate / tetrahydrofuran / 4 h / -78 - -20 °C
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran; hexane;
1.1: Alkylation / 2.1: Metallation / 2.2: Acylation;
DOI:10.1016/S0022-328X(99)00086-8
