3-(dimethylamino)-1-(2-fluorophenyl) propan-1-one hydrochloride

Base Information

• Chemical Name: 3-(dimethylamino)-1-(2-fluorophenyl) propan-1-one hydrochloride
• CAS No.: 16264-83-8
• Molecular Formula: C₁₁H₁₄FNO*ClH
• Molecular Weight: 231.698
• Mol file: 16264-83-8.mol

Synonyms:3-(dimethylamino)-1-(2-fluorophenyl) propan-1-one hydrochloride

Chemical Property of 3-(dimethylamino)-1-(2-fluorophenyl) propan-1-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-(dimethylamino)-1-(2-fluorophenyl) propan-1-one hydrochloride

There total 1 articles about 3-(dimethylamino)-1-(2-fluorophenyl) propan-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2'-Fluoroacetophenone (445-27-2) + N,N-dimethylammonium chloride (506-59-2) → 3-(dimethylamino)-1-(2-fluorophenyl) propan-1-one hydrochloride (16264-83-8)

Guidance literature:

With hydrogenchloride; In ethanol; for 22h; Reflux;

DOI:10.1021/acs.organomet.1c00237

Reference yield: 82.0%

3-(dimethylamino)-1-(2-fluorophenyl) propan-1-one hydrochloride (16264-83-8) + 1-(2-oxo-2-(2-pyridyl)ethyl)pyridinium iodide (26482-00-8) → C16H11FN2

Guidance literature:

1-(2-oxo-2-(2-pyridyl)ethyl)pyridinium iodide; With ammonium acetate; acetic acid; for 0.333333h; Reflux;

3-(dimethylamino)-1-(2-fluorophenyl) propan-1-one hydrochloride; for 22h; Reflux;

DOI:10.1021/acs.organomet.1c00237

Reference yield: 45.0%

1,2,4-Triazole (288-88-0) + 3-(dimethylamino)-1-(2-fluorophenyl) propan-1-one hydrochloride (16264-83-8) → 1-(2-fluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-1-one (1246193-74-7)

Guidance literature:

In water; for 5h; Reflux;

upstream raw materials:

formaldehyd

2'-Fluoroacetophenone

N,N-dimethylammonium chloride

Downstream raw materials:

1-(2-fluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-1-one