methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate

Base Information

Chemical Name:methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate
CAS No.:1058131-54-6
Molecular Formula:C₃₁H₃₆N₂O₆S
Molecular Weight:564.703
Hs Code.:

Synonyms:methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate

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Chemical Property of methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate

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Technology Process of methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate

There total 7 articles about methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 945686-02-2
13-cyclohexyl-3-methoxy-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

: 17854-68-1
(RS)-butane-2-sulfonamide

: 1058131-54-6
methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate

Guidance literature:: 13-cyclohexyl-3-methoxy-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 - 70 ℃; for 2.5h;

(RS)-butane-2-sulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 70 ℃;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 1058131-54-6
methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

1.2: 1 h / 0 - 20 °C

2.1: silver carbonate / tetrahydrofuran; dichloromethane / 0 - 20 °C / Molecular sieve

3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 0.25 h

3.2: 4 h / 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

5.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / 20 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.5 h / 20 - 70 °C

6.2: 70 °C

With lithium hydroxide; water; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 494799-76-7
2-bromo-3-cyclohexyl-1H-indole-6-carboxylic acid

: 1058131-54-6
methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver carbonate / tetrahydrofuran; dichloromethane / 0 - 20 °C / Molecular sieve

2.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 0.25 h

2.2: 4 h / 85 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

4.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.5 h / 20 - 70 °C

5.2: 70 °C

With sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;