methyl 5-((sec-butylsulfonyl)carbamoyl)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a]d[2]benzazepine-1a(2H)-carboxylate

Base Information

Chemical Name:methyl 5-((sec-butylsulfonyl)carbamoyl)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a]d[2]benzazepine-1a(2H)-carboxylate
CAS No.:1033904-00-5
Molecular Formula:C₃₂H₃₈N₂O₆S
Molecular Weight:578.73
Hs Code.:

Synonyms:methyl 5-((sec-butylsulfonyl)carbamoyl)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a]d[2]benzazepine-1a(2H)-carboxylate

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Chemical Property of methyl 5-((sec-butylsulfonyl)carbamoyl)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a]d[2]benzazepine-1a(2H)-carboxylate

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Technology Process of methyl 5-((sec-butylsulfonyl)carbamoyl)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a]d[2]benzazepine-1a(2H)-carboxylate

There total 8 articles about methyl 5-((sec-butylsulfonyl)carbamoyl)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a]d[2]benzazepine-1a(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1058131-54-6
methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate

: 1774-47-6
trimethylsulfoxonium iodide

: 1033904-00-5
methyl 5-((sec-butylsulfonyl)carbamoyl)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a]d[2]benzazepine-1a(2H)-carboxylate

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methyl 10-((sec-butylsulfonyl)carbamoyl)-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]-benzazepine-6-carboxylate; In N,N-dimethyl-formamide; for 0.25 - 0.333333h;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 1033904-00-5
methyl 5-((sec-butylsulfonyl)carbamoyl)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a]d[2]benzazepine-1a(2H)-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

1.2: 1 h / 0 - 20 °C

2.1: silver carbonate / tetrahydrofuran; dichloromethane / 0 - 20 °C / Molecular sieve

3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 0.25 h

3.2: 4 h / 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

5.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / 20 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.5 h / 20 - 70 °C

6.2: 70 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

7.2: 0.25 - 0.33 h

With lithium hydroxide; water; sodium hydride; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 494799-76-7
2-bromo-3-cyclohexyl-1H-indole-6-carboxylic acid

: 1033904-00-5
methyl 5-((sec-butylsulfonyl)carbamoyl)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a]d[2]benzazepine-1a(2H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: silver carbonate / tetrahydrofuran; dichloromethane / 0 - 20 °C / Molecular sieve

2.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 0.25 h

2.2: 4 h / 85 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

4.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.5 h / 20 - 70 °C

5.2: 70 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 0.25 - 0.33 h

With sodium hydride; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;