(S)-O-methyl ((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamothioate

Base Information

Chemical Name:(S)-O-methyl ((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamothioate
CAS No.:1430321-48-4
Molecular Formula:C₁₈H₂₆FN₃O₃SSi
Molecular Weight:411.573
Hs Code.:

Synonyms:(S)-O-methyl ((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamothioate

Suppliers and Price of (S)-O-methyl ((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamothioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-O-methyl ((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamothioate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-O-methyl ((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamothioate

There total 12 articles about (S)-O-methyl ((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 67-56-1
methanol

: 463-71-8
thiophosgene

: 1430321-44-0
(S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one

: 1430321-48-4
(S)-O-methyl ((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamothioate

Guidance literature:: thiophosgene; (S)-5-(aminoniethyl)-3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)oxazolidin-2-one; With sodium hydrogencarbonate; In dichloromethane; at 0 - 25 ℃; for 3h;

methanol; In dichloromethane; Reflux;

Reference yield:

: 1430321-42-8
1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

: 1430321-48-4
(S)-O-methyl ((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamothioate

Guidance literature:: Multi-step reaction with 6 steps

1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 8 h / 1810.07 Torr

2: sodium hydrogencarbonate / tetrahydrofuran / 5 h / 0 - 25 °C

3: lithium tert-butoxide / N,N-dimethyl-formamide / 45 h / 0 - 25 °C

4: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

5: sodium hydrogencarbonate / dichloromethane / 3 h / 0 - 25 °C

6: Reflux

With palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; lithium tert-butoxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1430321-43-9
benzyl 4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenylcarbamate

: 1430321-48-4
(S)-O-methyl ((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamothioate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium tert-butoxide / N,N-dimethyl-formamide / 45 h / 0 - 25 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

3: sodium hydrogencarbonate / dichloromethane / 3 h / 0 - 25 °C

4: Reflux

With sodium hydrogencarbonate; trifluoroacetic acid; lithium tert-butoxide; In dichloromethane; N,N-dimethyl-formamide;