methyl(2-methyldiphenylphosphino)-1-chloro-3-diphenylphosphinopropane

Base Information

• Chemical Name: methyl(2-methyldiphenylphosphino)-1-chloro-3-diphenylphosphinopropane
• CAS No.: 155932-48-2
• Molecular Formula: C₂₉H₂₉ClP₂
• Molecular Weight: 474.95
• Mol file: 155932-48-2.mol

Synonyms:methyl(2-methyldiphenylphosphino)-1-chloro-3-diphenylphosphinopropane

Chemical Property of methyl(2-methyldiphenylphosphino)-1-chloro-3-diphenylphosphinopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of methyl(2-methyldiphenylphosphino)-1-chloro-3-diphenylphosphinopropane

There total 5 articles about methyl(2-methyldiphenylphosphino)-1-chloro-3-diphenylphosphinopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-(Brommethyl)-2-(chlormethyl)-1-(methylsulfonyloxy)propan (175222-31-8) + diphenylphosphane (829-85-6) → methyl(2-methyldiphenylphosphino)-1-chloro-3-diphenylphosphinopropane (155932-48-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; 1) -40 deg C, 2 h, 2) -20 deg C, 2 h, to r.t., 18 h;

DOI:10.1002/cber.19961290119

Reference yield: 32.0%

1,3-dichloro-2-(chloromethyl)-2-methylpropane (1067-09-0) + diphenylphosphane (829-85-6) → methyl(2-methyldiphenylphosphino)-1-chloro-3-diphenylphosphinopropane (155932-48-2)

Guidance literature:

diphenylphosphane; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.583333h; Inert atmosphere; Schlenk technique;

1,3-dichloro-2-(chloromethyl)-2-methylpropane; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 64h; Inert atmosphere; Schlenk technique;

DOI:10.1002/zaac.202100166

Reference yield: 16.0%

1,3-dichloro-2-(chloromethyl)-2-methylpropane (1067-09-0) + diphenylphosphane (829-85-6) → (3-chloro-2-(chloromethyl)-2-methylpropyl)-diphenylphosphane + methyl(2-methyldiphenylphosphino)-1-chloro-3-diphenylphosphinopropane (155932-48-2) + [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] (22031-12-5)

Guidance literature:

With potassium hydroxide; potassium carbonate; In dimethyl sulfoxide; 1.) 50 deg C, 2 h, 2.) 60 deg C, 6 h;

DOI:10.1016/0022-328X(94)80044-8

upstream raw materials:

1,3-dichloro-2-(chloromethyl)-2-methylpropane

diphenylphosphane

2-(Brommethyl)-2-(chlormethyl)-1-(methylsulfonyloxy)propan

dibenzylphosphine

Downstream raw materials:

1-benzylthio-3-diphenylphosphanyl-2-diphenylphosphanylmethyl-2-methylpropane

1-[bis(o-tolyl)phosphanyl]-3-(diphenylphosphanyl)-2-(diphenylphosphanylmethyl)-2-methylpropane

[1,1-bis(diphenylphosphanylmethyl)-1-(phenylphosphanylmethyl)]ethane

3-diphenylphosphanyl-2-diphenylphosphanylmethyl-2-methyl-1-propanethiol