C₂₂H₂₇ClO₈

Base Information

• Chemical Name: C₂₂H₂₇ClO₈
• CAS No.: 1320259-71-9
• Molecular Formula: C₂₂H₂₇ClO₈
• Molecular Weight: 454.905
• Mol file: 1320259-71-9.mol

Synonyms:C₂₂H₂₇ClO₈

Chemical Property of C₂₂H₂₇ClO₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₂H₂₇ClO₈

There total 13 articles about C₂₂H₂₇ClO₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H27ClO9 (1346458-46-5) → C22H27ClO8 (1320259-71-9)

Guidance literature:

With 20 % Pd(OH)2/C; hydrogen; In methanol; at 20 ℃; for 2h;

DOI:10.1021/ol201561w

Reference yield:

3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde (1320259-65-1) → C22H27ClO8 (1320259-71-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / 0 - 25 °C / Inert atmosphere

1.2: 4 h / 0 - 25 °C / Inert atmosphere

2.1: Dess-Martin periodane / dichloromethane / 3.5 h / 25 °C / Inert atmosphere

3.1: 20 % Pd(OH)2/C; hydrogen / methanol / 20 °C

4.1: 20 % Pd(OH)2/C; hydrogen / methanol / 2 h / 20 °C

With n-butyllithium; 20 % Pd(OH)2/C; hydrogen; Dess-Martin periodane; In tetrahydrofuran; methanol; hexane; dichloromethane;

DOI:10.1021/ol201561w

Reference yield:

2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol (1320259-67-3) → C22H27ClO8 (1320259-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 3.5 h / 25 °C / Inert atmosphere

2: 20 % Pd(OH)2/C; hydrogen / methanol / 20 °C

3: 20 % Pd(OH)2/C; hydrogen / methanol / 2 h / 20 °C

With 20 % Pd(OH)2/C; hydrogen; Dess-Martin periodane; In methanol; dichloromethane;

DOI:10.1021/ol201561w

upstream raw materials:

3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde

2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol

[2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-4-methoxy-2-(methoxymethoxy)-6-[(phenylmethoxy)methyl]phenyl]-methanone

[2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone