C₁₀H₁₂N₄O₂

Base Information

• Chemical Name: C₁₀H₁₂N₄O₂
• CAS No.: 1373496-76-4
• Molecular Formula: C₁₀H₁₂N₄O₂
• Molecular Weight: 220.231
• Mol file: 1373496-76-4.mol

Synonyms:C₁₀H₁₂N₄O₂

Chemical Property of C₁₀H₁₂N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₁₂N₄O₂

There total 3 articles about C₁₀H₁₂N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

C8H7N3O3 (1373496-72-0) + ethanamine hydrochloride (557-66-4) → C10H12N4O2 (1373496-76-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -5 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo300063u

Reference yield:

2-amino-phenol (95-55-6) → C10H12N4O2 (1373496-76-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.08 h / -5 - -3 °C / Inert atmosphere

1.2: Inert atmosphere

1.3: 2 h / 0 °C / Inert atmosphere

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere

3.2: pH 4

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / -5 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; lithium hydroxide monohydrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo300063u

Reference yield:

2-azidophenol (24541-44-4) → C10H12N4O2 (1373496-76-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere

2.2: pH 4

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / -5 - 20 °C / Inert atmosphere

With dmap; lithium hydroxide monohydrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo300063u

upstream raw materials:

C₈H₇N₃O₃

ethanamine hydrochloride

2-azidophenol

2-amino-phenol

Downstream raw materials:

C₂₄H₂₉N₅O₄