Methyl (R)-(-)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate

Base Information

Chemical Name:Methyl (R)-(-)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate
CAS No.:124876-74-0
Molecular Formula:C₁₅H₂₄O₃Si
Molecular Weight:280.439
Hs Code.:

Synonyms:Methyl (R)-(-)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl (R)-(-)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate

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Technology Process of Methyl (R)-(-)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate

There total 2 articles about Methyl (R)-(-)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 67-56-1
methanol

: 611-71-2
(R)-Mandelic Acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 124876-74-0
Methyl (R)-(-)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate

Guidance literature:: methanol; (R)-Mandelic Acid; With acetyl chloride; at 20 ℃;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In dichloromethane; at 40 ℃; for 5h;
DOI:10.1039/c7ob01283g

Reference yield:

: 611-71-2
(R)-Mandelic Acid

: 124876-74-0
Methyl (R)-(-)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH / 3 h / Heating

2: imidazole / dimethylformamide / 12 h / 22 °C

With 1H-imidazole; toluene-4-sulfonic acid; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(96)01972-7