*,R^*)>-1-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: *,R^*)>-1-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester
• CAS No.: 117085-65-1
• Molecular Formula: C₃₀H₃₈N₂O₇
• Molecular Weight: 538.641

Synonyms:*,R^*)>-1-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester

Chemical Property of *,R^*)>-1-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of *,R^*)>-1-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester

There total 3 articles about *,R^*)>-1-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid (59221-35-1) → *,R*)>-1-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester (117085-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 1 h / 0 °C

2: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature

With dmap; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm00167a028

Reference yield:

pivaloyl chloride (3282-30-2) → *,R*)>-1-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester (117085-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 1 h / 0 °C

2: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature

With dmap; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm00167a028

Reference yield:

(S)-6-Benzyloxycarbonylamino-2-(2,2-dimethyl-propionyloxy)-hexanoic acid (126111-16-8) + Ethyl (S)-indoline-2-carboxylate hydrochloride (79854-42-5) → *,R*)>-1-<2-(2,2-dimethyl-1-oxopropoxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester (117085-65-1)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; for 16h; Yield given; Ambient temperature;

DOI:10.1021/jm00167a028

upstream raw materials:

(S)-6-Benzyloxycarbonylamino-2-(2,2-dimethyl-propionyloxy)-hexanoic acid

Ethyl (S)-indoline-2-carboxylate hydrochloride

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

pivaloyl chloride

Downstream raw materials:

(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester

*,R^*)>-2,3-dihydro-1-<2-<oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester

*,R^*)>-2,3-dihydro-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-1H-indole-2-carboxylic acid diphenylmethyl ester

*,R^*)>-2,3-dihydro-1-<6-amino-2-<oxy>-1-oxohexyl>-1H-indole-2-carboxylic acid

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