6-(4-(ethoxycarbonyl)phenoxy)hexylboronic acid

Base Information

• Chemical Name: 6-(4-(ethoxycarbonyl)phenoxy)hexylboronic acid
• CAS No.: 1440956-35-3
• Molecular Formula: C₁₅H₂₃BO₅
• Molecular Weight: 294.156
• Mol file: 1440956-35-3.mol

Synonyms:6-(4-(ethoxycarbonyl)phenoxy)hexylboronic acid

Chemical Property of 6-(4-(ethoxycarbonyl)phenoxy)hexylboronic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 6-(4-(ethoxycarbonyl)phenoxy)hexylboronic acid

There total 2 articles about 6-(4-(ethoxycarbonyl)phenoxy)hexylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexyl)oxy)benzoate (1440955-95-2) → 6-(4-(ethoxycarbonyl)phenoxy)hexylboronic acid (1440956-35-3)

Guidance literature:

ethyl 4-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexyl)oxy)benzoate; With sodium periodate; In tetrahydrofuran; water; for 0.0833333h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1002/anie.201206681

Reference yield:

6-(4-carbethoxyphenoxy)hexyl bromide (73515-07-8) → 6-(4-(ethoxycarbonyl)phenoxy)hexylboronic acid (1440956-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide; triphenylphosphine; lithium methanolate / N,N-dimethyl-formamide / 18 h / 30 °C / Schlenk technique; Inert atmosphere

2.1: sodium periodate / water; tetrahydrofuran / 0.08 h

2.2: 20 °C

With sodium periodate; copper(l) iodide; lithium methanolate; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1002/anie.201206681

Reference yield: 65.0%

6-(4-(ethoxycarbonyl)phenoxy)hexylboronic acid (1440956-35-3) + (trifluoromethyl)trimethylsilane (81290-20-2) → ethyl 4-(7,7,7-trifluoroheptyloxy)benzoate (1440956-11-5)

Guidance literature:

With potassium fluoride; copper(l) iodide; silver tetrafluoroborate; 3,4,7,8-Tetramethyl-o-phenanthrolin; silver fluoride; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Glovebox; Inert atmosphere;

DOI:10.1002/anie.201206681

upstream raw materials:

ethyl 4-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexyl)oxy)benzoate

6-(4-carbethoxyphenoxy)hexyl bromide

Downstream raw materials:

ethyl 4-(7,7,7-trifluoroheptyloxy)benzoate