73515-07-8Relevant academic research and scientific papers
CHEMOSELECTIVE SENSITIVITY BOOSTER FOR TAGGING A PEPTIDE, PEPTIDE CONJUGATE, OR SIMILAR REACTIVE MOLECULE
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, (2020/12/29)
The invention pertains to chemoselective sensitivity booster for tagging a peptide, peptide conjugate, or similar reactive molecule for analysis of a peptide, protein, antibody, protein bioconjugate, antibody bioconjugate, and similar analytes. The sensitivity booster comprises of sp2 or sp3 nitrogen centers in combination with hydrophobic carbon chains linked with an electrophile or nucleophile for attachment with a peptide, peptide conjugate, or molecules with similar reactivity.
Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, antibodies, and protein bioconjugates
Singudas, Rohith,Reddy, Neelesh C.,Rai, Vishal
, p. 9979 - 9982 (2019/08/22)
A chemical tag enhances peptide detection by multiple orders in mass spectrometry. The substantial improvement in the peptide mapping along with simplified and enhanced fragmentation pattern enables the unambiguous sequencing of a protein and antibody. The chemoselective sensitivity booster provides a tool for remarkably improved analysis of protein bioconjugates.
Facile fabrication of color tunable film and fiber nanocomposites via thiol click chemistry
Boyd, Darryl A.,Naciri, Jawad,Fontana, Jake,Pacardo, Dennis B.,Shields, Adam R.,Verbarg, Jasenka,Spillmann, Christopher M.,Ligler, Frances S.
, p. 695 - 704 (2014/02/14)
A simple method for the fabrication of nanocomposite materials using thiol click chemistry is reported. The thiol click nanocomposite materials produced each displayed distinctive colors which were found to be dependent on both the ligand used to function
Synthesis and polymerization of liquid crystals containing vinyl and mercapto groups
Lub, Johan,Broer, Dirk Jan,Van Den Brock, Nel
, p. 2281 - 2288 (2007/10/03)
Liquid-crystalline monomers containing two vinyl groups, two mercapto groups, or a 1:1 combination of the two have been synthesized and characterized in terms of their mesomorphic properties. These monomers can be photopolymerized in situ in an appropriate ratio of vinyl and mercapto groups to form highly ordered liquid-crystalline main-chain polymers. During polymerization in the nematic phase the appearance changes from clear in the highly aligned bire-fringent state to opaque. This effect is probably due to scattering which is caused by the disturbance of the macro alignment as a result of the polymerization shrinkage and/or phase separation. In some cases, the reaction mixtures pass from the nematic to the crystalline state which results in a reduction in the degree of conversion and also in a change in the microcrystalline state. Crystallization can be suppressed by promoting asymmetry of the molecular structure which leads to a higher degree of conversion. Wiley-VCH Verlag GmbH, 1997.
Alkoxylated phenyl and coumarin derivatives useful in the treatment of viral infections
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, (2008/06/13)
Alkoxylated phenyl and coumarin derivatives useful in the treatment of viral infections are disclosed. The compounds are particularly useful in the treatment of picornaviruses, and more particularly in the treatment of rhinoviruses.
Design of spatial disposition of anionic porphyrins in matrices of ammonium bilayer membranes
Ishikawa, Yuichi,Kunitake, Toyoki
, p. 621 - 630 (2007/10/02)
A methodology to place charged porphyrin derivatives in specific spatial arrangements in matrices of ammonium bilayer membranes was explored. Aqueous mixtures of anionic copper(II) porphyrins and bilayer dispersions of single-chain and double-chain ammoni
Di-heterocyclic compounds and their use as antiviral agents
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, (2008/06/13)
Compounds of the formulas: STR1 wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.
