3-(2-cyanoethyl)-1-<5-O--β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione

Base Information

Chemical Name:3-(2-cyanoethyl)-1-<5-O--β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione
CAS No.:153631-17-5
Molecular Formula:C₃₄H₃₅N₃O₈
Molecular Weight:613.667
Hs Code.:

3-(2-cyanoethyl)-1-<5-O-<bis(4-methoxyphenyl)phenylmethyl>-β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione

Synonyms:3-(2-cyanoethyl)-1-<5-O--β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-cyanoethyl)-1-<5-O--β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione

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Technology Process of 3-(2-cyanoethyl)-1-<5-O--β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione

There total 5 articles about 3-(2-cyanoethyl)-1-<5-O--β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 107-13-1,25014-41-9
acrylonitrile

: 138239-62-0
1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

: 153631-17-5
3-(2-cyanoethyl)-1-<5-O--β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione

Guidance literature:: With pyridine; tetra(n-butyl)ammonium hydroxide; In acetonitrile; for 48h; Heating;
DOI:10.1002/jhet.5570300522

Reference yield:

: 3180-76-5
2',3',5'-tri-O-benzoyluridine

: 153631-17-5
3-(2-cyanoethyl)-1-<5-O--β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaOMe / methanol / 24 h / Ambient temperature

2: 71 percent / pyridine / 1.25 h / Ambient temperature

3: 65 percent / tetrabutylammonium hydroxide, pyridine / acetonitrile / 48 h / Heating

With pyridine; tetra(n-butyl)ammonium hydroxide; sodium methylate; In methanol; acetonitrile;
DOI:10.1002/jhet.5570300522

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 153631-17-5
3-(2-cyanoethyl)-1-<5-O--β-D-ribofuranosyl>-5-methyl-1-1H,3H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1,1,1,3,3,3-hexamethyldisilazane, chlorotrimethyl silane / acetonitrile / 4 h / Heating

2: acetonitrile / 0.5 h / Heating

3: 90 percent / NaOMe / methanol / 24 h / Ambient temperature

4: 71 percent / pyridine / 1.25 h / Ambient temperature

5: 65 percent / tetrabutylammonium hydroxide, pyridine / acetonitrile / 48 h / Heating

With pyridine; chloro-trimethyl-silane; tetra(n-butyl)ammonium hydroxide; sodium methylate; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; acetonitrile;
DOI:10.1002/jhet.5570300522