4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde

Base Information

Chemical Name:4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde
CAS No.:1055306-31-4
Molecular Formula:C₁₇H₁₂ClFN₂O₅S₂
Molecular Weight:442.876
Hs Code.:

Synonyms:4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde

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Chemical Property of 4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde

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Technology Process of 4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde

There total 6 articles about 4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 928325-27-3
4-chloro-5-(2-fluoropyridin-3-yl)-1H-pyrrole-3-carbaldehyde

: 5335-40-0
3-(methylsulfonyl)benzenesulfonyl chloride

: 1055306-31-4
4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde

Guidance literature:: 4-chloro-5-(2-fluoropyridin-3-yl)-1H-pyrrole-3-carbaldehyde; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

With 15-crown-5; In tetrahydrofuran; for 0.0833333h;

3-(methylsulfonyl)benzenesulfonyl chloride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 881673-82-1
5-bromo-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

: 1055306-31-4
4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 80 °C

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 80 °C

4.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

4.2: 0.08 h

4.3: 1 h / 20 °C

With methanol; sodium hydroxide; N-chloro-succinimide; water; sodium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 881676-32-0
5-bromo-1H-pyrrole-3-carboxaldehyde

: 1055306-31-4
4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 80 °C

3.1: methanol; sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 80 °C

5.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

5.2: 0.08 h

5.3: 1 h / 20 °C

With methanol; sodium hydroxide; N-chloro-succinimide; water; sodium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;