1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile

Base Information

Chemical Name:1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile
CAS No.:1374461-73-0
Molecular Formula:C₄₀H₄₄F₃N₃O₃
Molecular Weight:671.803
Hs Code.:

Synonyms:1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile

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Chemical Property of 1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile

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Technology Process of 1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile

There total 11 articles about 1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160969-00-6
1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene

: 1374461-74-1
1-[3-(benzyloxy)propyl]-5-[(2R)-2-{[(1R)-1-phenylethyl]amino}propyl]indoline-7-carbonitrile

: 1374461-73-0
1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 110 ℃; for 21.5h; Sealed tube;

Reference yield:

: 100-39-0
benzyl bromide

: 1374461-73-0
1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 22 h / Reflux

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25.5 h / 130 °C

3.1: trichlorophosphate / 1 h / 0 - 5 °C

3.2: 21.17 h / 20 °C / Cooling

3.3: 4 h / 35 °C

4.1: bromine; acetic acid / 0.67 h / 20 °C

5.1: N,N-dimethyl-formamide / 150 °C / Inert atmosphere

5.2: 0.25 h / 70 °C

6.1: ammonium acetate / 4.5 h / 125 °C

6.2: 0.5 h / 20 °C

7.1: hydrogenchloride; water; iron; iron(III) chloride / 2.5 h / 60 - 90 °C

8.1: tetrahydrofuran / 0.17 h / 20 °C

8.2: 24 h / 20 °C

9.1: sodium carbonate / water / 0.5 h / 20 °C

10.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 21.5 h / 110 °C / Sealed tube

With hydrogenchloride; iron(III) chloride; ammonium acetate; water; bromine; iron; sodium carbonate; potassium carbonate; acetic acid; potassium iodide; sodium hydroxide; trichlorophosphate; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1375180-30-5
1-[3-(benzyloxy)propyl]-5-formylindoline-7-carbonitrile

: 1374461-73-0
1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / 4.5 h / 125 °C

1.2: 0.5 h / 20 °C

2.1: hydrogenchloride; water; iron; iron(III) chloride / 2.5 h / 60 - 90 °C

3.1: tetrahydrofuran / 0.17 h / 20 °C

3.2: 24 h / 20 °C

4.1: sodium carbonate / water / 0.5 h / 20 °C

5.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 21.5 h / 110 °C / Sealed tube

With hydrogenchloride; iron(III) chloride; ammonium acetate; water; iron; sodium carbonate; potassium carbonate; potassium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide;