3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester

Base Information

Chemical Name:3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester
CAS No.:1380646-56-9
Molecular Formula:C₂₁H₂₅FO₂S
Molecular Weight:360.493
Hs Code.:

Synonyms:3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester

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Chemical Property of 3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester

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Technology Process of 3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester

There total 3 articles about 3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1380646-55-8
(2-methyl-4-methylsulfanylphenyl)-acetic acid tert-butyl ester

: 459-46-1
4-Fluorobenzyl bromide

: 1380646-56-9
3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester

Guidance literature:: (2-methyl-4-methylsulfanylphenyl)-acetic acid tert-butyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

4-Fluorobenzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;

Reference yield:

: 321745-86-2
2-tert-butoxy-2-oxoethylzinc chloride

: 1380646-56-9
3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / diethyl ether; tetrahydrofuran / 0.08 h / 120 °C / Inert atmosphere; Microwave reactor

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

With sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 90532-02-8
1-bromo-2-methyl-4-methylsulfanylbenzene

: 1380646-56-9
3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / diethyl ether; tetrahydrofuran / 0.08 h / 120 °C / Inert atmosphere; Microwave reactor

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

With sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; mineral oil;