N-(3-methyl-but-2-en-1-yl)-N-(2-bromoethyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(3-methyl-but-2-en-1-yl)-N-(2-bromoethyl)-4-methylbenzenesulfonamide
• CAS No.: 1256292-34-8
• Molecular Formula: C₁₄H₂₀BrNO₂S
• Molecular Weight: 346.288
• Mol file: 1256292-34-8.mol

Synonyms:N-(3-methyl-but-2-en-1-yl)-N-(2-bromoethyl)-4-methylbenzenesulfonamide

Chemical Property of N-(3-methyl-but-2-en-1-yl)-N-(2-bromoethyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-methyl-but-2-en-1-yl)-N-(2-bromoethyl)-4-methylbenzenesulfonamide

There total 5 articles about N-(3-methyl-but-2-en-1-yl)-N-(2-bromoethyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-methyl-N-(3-methylbut-2-enyl)benzenesulfonamide (78388-19-9) + ethylene dibromide (106-93-4) → N-(3-methyl-but-2-en-1-yl)-N-(2-bromoethyl)-4-methylbenzenesulfonamide (1256292-34-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃; for 3h;

DOI:10.1021/ol3028913

Reference yield:

N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide (14316-14-4) → N-(3-methyl-but-2-en-1-yl)-N-(2-bromoethyl)-4-methylbenzenesulfonamide (1256292-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetone / 16 h / Reflux

2: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 16 h / 0 - 20 °C

With carbon tetrabromide; potassium carbonate; triphenylphosphine; potassium iodide; In tetrahydrofuran; acetone;

DOI:10.1021/jacs.7b06794

Reference yield:

prenyl bromide (870-63-3) → N-(3-methyl-but-2-en-1-yl)-N-(2-bromoethyl)-4-methylbenzenesulfonamide (1256292-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetone / 16 h / Reflux

2: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 16 h / 0 - 20 °C

With carbon tetrabromide; potassium carbonate; triphenylphosphine; potassium iodide; In tetrahydrofuran; acetone;

DOI:10.1021/jacs.7b06794

upstream raw materials:

4-methyl-N-(3-methylbut-2-enyl)benzenesulfonamide

ethylene dibromide

N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

3-methyl-2-buten-1-ol

Downstream raw materials:

3-isopropyl-1-tosylpyrrolidine

N-(2-iodoethyl)-4-methyl-N-(3-methylbut-2-enyl)benzenesulfonamide

3-(prop-1-en-2-yl)-1-tosylpyrrolidine

C₁₄H₂₀⁽²⁾HNO₂S