Technology Process of C27H32ClN3O5
There total 7 articles about C27H32ClN3O5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloro-3-methylbenzoic acid;
With
diphenyl phosphoryl azide; triethylamine;
In
tetrahydrofuran;
for 3h;
Reflux;
6-amino-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester;
In
tetrahydrofuran;
for 1h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; methanol / 1 h / 0 °C
2.1: pyridine / dichloromethane / 0 - 20 °C
2.2: 3.5 h / 20 °C
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 8 h / 20 °C
4.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 3 h / Reflux
4.2: 1 h / Reflux
With
pyridine; methanol; sodium tetrahydroborate; diphenyl phosphoryl azide; hydrogen; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride / water; acetone / 15 h / 20 °C
2.1: sodium tetrahydroborate; methanol / 1 h / 0 °C
3.1: pyridine / dichloromethane / 0 - 20 °C
3.2: 3.5 h / 20 °C
4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 8 h / 20 °C
5.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 3 h / Reflux
5.2: 1 h / Reflux
With
pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; diphenyl phosphoryl azide; hydrogen; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone;
