2-[1-phenyl-2-(phenyl-hydrazono)-2-thiocyanato-ethylidene]-malonic acid diethyl ester

Base Information

• Chemical Name: 2-[1-phenyl-2-(phenyl-hydrazono)-2-thiocyanato-ethylidene]-malonic acid diethyl ester
• CAS No.: 298184-03-9
• Molecular Formula: C₂₂H₂₁N₃O₄S
• Molecular Weight: 423.492
• Mol file: 298184-03-9.mol

Synonyms:2-[1-phenyl-2-(phenyl-hydrazono)-2-thiocyanato-ethylidene]-malonic acid diethyl ester

Chemical Property of 2-[1-phenyl-2-(phenyl-hydrazono)-2-thiocyanato-ethylidene]-malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[1-phenyl-2-(phenyl-hydrazono)-2-thiocyanato-ethylidene]-malonic acid diethyl ester

There total 5 articles about 2-[1-phenyl-2-(phenyl-hydrazono)-2-thiocyanato-ethylidene]-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzene diazonium chloride (100-34-5) + diethyl 2-phenyl-3-thiocyanatopropene-1,1-dicarboxylate (298184-02-8) → 2-[1-phenyl-2-(phenyl-hydrazono)-2-thiocyanato-ethylidene]-malonic acid diethyl ester (298184-03-9)

Guidance literature:

With sodium acetate; In ethanol; at 0 - 20 ℃;

DOI:10.1080/10426509908044978

Reference yield:

2-(1-phenylethylidene)malonic acid diethyl ester (5294-56-4) → 2-[1-phenyl-2-(phenyl-hydrazono)-2-thiocyanato-ethylidene]-malonic acid diethyl ester (298184-03-9)

Guidance literature:

Multi-step reaction with 3 steps

1: NBS; dibenzoyl peroxide / CCl₄ / 2 h / Heating

2: 80 percent / ethanol / 3 h / Heating

3: 85 percent / NaOAc / ethanol / 0 - 20 °C

With N-Bromosuccinimide; sodium acetate; dibenzoyl peroxide; In tetrachloromethane; ethanol; 1: Bromination / 2: Condensation / 3: Condensation;

DOI:10.1080/10426509908044978

Reference yield:

acetophenone (98-86-2) → 2-[1-phenyl-2-(phenyl-hydrazono)-2-thiocyanato-ethylidene]-malonic acid diethyl ester (298184-03-9)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium acetate; AcOH / benzene / 7 h / Heating

2: NBS; dibenzoyl peroxide / CCl₄ / 2 h / Heating

3: 80 percent / ethanol / 3 h / Heating

4: 85 percent / NaOAc / ethanol / 0 - 20 °C

With ammonium acetate; N-Bromosuccinimide; sodium acetate; acetic acid; dibenzoyl peroxide; In tetrachloromethane; ethanol; benzene; 1: Condensation / 2: Bromination / 3: Condensation / 4: Condensation;

DOI:10.1080/10426509908044978

upstream raw materials:

benzene diazonium chloride

diethyl 2-phenyl-3-thiocyanatopropene-1,1-dicarboxylate

2-(1-phenylethylidene)malonic acid diethyl ester

acetophenone