2-methoxy-N,N-dimethyl-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzamide

Base Information

Chemical Name:2-methoxy-N,N-dimethyl-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzamide
CAS No.:1431541-47-7
Molecular Formula:C₃₀H₃₁N₅O₃
Molecular Weight:509.608
Hs Code.:

Synonyms:2-methoxy-N,N-dimethyl-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzamide

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Chemical Property of 2-methoxy-N,N-dimethyl-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzamide

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Technology Process of 2-methoxy-N,N-dimethyl-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzamide

There total 8 articles about 2-methoxy-N,N-dimethyl-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1431542-36-7
2-methoxy-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzoic acid

: 124-40-3
dimethyl amine

: 1431541-47-7
2-methoxy-N,N-dimethyl-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzamide

Guidance literature:: 2-methoxy-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

dimethyl amine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1431542-28-7
3-(6-bromo-quinazolin-4-yl)-benzoic acid

: 1431541-47-7
2-methoxy-N,N-dimethyl-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 0.08 h / 20 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation; Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.17 h / 20 °C

4.2: 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1431542-29-8
3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester

: 1431541-47-7
2-methoxy-N,N-dimethyl-5-{4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 0.08 h / 20 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation; Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.17 h / 20 °C

5.2: 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; water; potassium acetate; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;