ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate

Base Information

Chemical Name:ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate
CAS No.:1160825-89-7
Molecular Formula:C₁₉H₂₃FN₄O₅
Molecular Weight:406.414
Hs Code.:

Synonyms:ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate

Suppliers and Price of ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate

There total 5 articles about ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1163720-66-8
4-(4-N-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2,3-diaminopyridine

: 541-41-3
chloroformic acid ethyl ester

: 1160825-89-7
ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate

Guidance literature:: With pyridine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm900242c

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1160825-89-7
ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: indium(III) chloride / 2 h / 35 °C / Neat (no solvent)

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 110 °C

3.1: hydrogen / 10% palladium on activated charcoal / ethyl acetate; ethanol / 5 h

4.1: pyridine / tetrahydrofuran / 24.5 h / 0 - 20 °C

With pyridine; hydrogen; sodium hydride; indium(III) chloride; 10% palladium on activated charcoal; In tetrahydrofuran; ethanol; dimethyl sulfoxide; ethyl acetate; mineral oil;

Reference yield:

: 911297-02-4
N-(2-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester

: 1160825-89-7
ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 110 °C

2.1: hydrogen / 10% palladium on activated charcoal / ethyl acetate; ethanol / 5 h

3.1: pyridine / tetrahydrofuran / 24.5 h / 0 - 20 °C

With pyridine; hydrogen; sodium hydride; 10% palladium on activated charcoal; In tetrahydrofuran; ethanol; dimethyl sulfoxide; ethyl acetate; mineral oil;