1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine

Base Information

Chemical Name:1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine
CAS No.:1312605-96-1
Molecular Formula:C₁₇H₁₆FN₃O₂S
Molecular Weight:345.397
Hs Code.:

Synonyms:1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine

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Chemical Property of 1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine

Chemical Property:

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Technology Process of 1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine

There total 15 articles about 1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312605-95-0
2-(1-(7-Fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione

: 1312605-96-1
1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine

Guidance literature:: With hydrazine hydrate; In ethanol; at 25 ℃;

Reference yield:

: 1312605-88-1
5-fluoro-3-nitro-2-vinylpyridine

: 1312605-96-1
1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 11 steps

1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; tetrahydrofuran / 6 h / 25 °C

2: sodium periodate; water / tert-butyl alcohol; tetrahydrofuran / 8 h / 25 °C

3: toluene-4-sulfonic acid / toluene / 25 - 120 °C

4: hydrogen / palladium on carbon / ethanol / 25 °C / Inert atmosphere

5: water; lithium chloride / dimethyl sulfoxide / 16 h / 90 °C

6: cerium(III) chloride heptahydrate / 3 h / 100 °C

7: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C

8: dipyridinium dichromate / dichloromethane / 25 °C

9: tetrahydrofuran / 2 h / 0 °C

10: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 °C

11: hydrazine hydrate / ethanol / 25 °C

With sodium periodate; osmium(VIII) oxide; dipyridinium dichromate; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; water; hydrogen; diisobutylaluminium hydride; hydrazine hydrate; 4-methylmorpholine N-oxide; triphenylphosphine; lithium chloride; palladium on carbon; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; toluene; tert-butyl alcohol;

Reference yield:

: 652160-72-0
2-bromo-5-fluoro-3-nitropyridine

: 1312605-96-1
1-(7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 12 steps

1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere

2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol; tetrahydrofuran / 6 h / 25 °C

3: sodium periodate; water / tert-butyl alcohol; tetrahydrofuran / 8 h / 25 °C

4: toluene-4-sulfonic acid / toluene / 25 - 120 °C

5: hydrogen / palladium on carbon / ethanol / 25 °C / Inert atmosphere

6: water; lithium chloride / dimethyl sulfoxide / 16 h / 90 °C

7: cerium(III) chloride heptahydrate / 3 h / 100 °C

8: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C

9: dipyridinium dichromate / dichloromethane / 25 °C

10: tetrahydrofuran / 2 h / 0 °C

11: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 °C

12: hydrazine hydrate / ethanol / 25 °C

With sodium periodate; osmium(VIII) oxide; dipyridinium dichromate; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; water; hydrogen; diisobutylaluminium hydride; hydrazine hydrate; 4-methylmorpholine N-oxide; triphenylphosphine; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium on carbon; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; toluene; tert-butyl alcohol;