[1-(2-benzyloxy-4-benzyloxymethyl-6-nitro-benzyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[1-(2-benzyloxy-4-benzyloxymethyl-6-nitro-benzyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane
CAS No.:704906-88-7
Molecular Formula:C₃₁H₃₇NO₅Si
Molecular Weight:531.724
Hs Code.:

[1-(2-benzyloxy-4-benzyloxymethyl-6-nitro-benzyl)-prop-2-ynyloxy]-<i>tert</i>-butyl-dimethyl-silane

Synonyms:[1-(2-benzyloxy-4-benzyloxymethyl-6-nitro-benzyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

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Chemical Property of [1-(2-benzyloxy-4-benzyloxymethyl-6-nitro-benzyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

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Technology Process of [1-(2-benzyloxy-4-benzyloxymethyl-6-nitro-benzyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

There total 9 articles about [1-(2-benzyloxy-4-benzyloxymethyl-6-nitro-benzyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100-39-0
benzyl bromide

: 704906-84-3
{3-benzyloxy-4-[2-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-5-nitro-phenyl}-methanol

: 704906-88-7
[1-(2-benzyloxy-4-benzyloxymethyl-6-nitro-benzyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
DOI:10.1021/ol049583y

Reference yield:

: 704906-38-7
3-Benzyloxy-4-((R)-2-hydroxy-4-trimethylsilanyl-but-3-ynyl)-5-nitro-benzoic acid methyl ester

: 704906-88-7
[1-(2-benzyloxy-4-benzyloxymethyl-6-nitro-benzyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / imidazole / CH₂Cl₂ / 4 h / 20 °C

2: 99 percent / diisobutylaluminum hydride / hexane; tetrahydrofuran / 1 h / -78 - 0 °C

3: 97 percent / potassium carbonate / methanol / 1.5 h / 20 °C

4: 96 percent / tetrabutylammonium iodide; sodium hydride / tetrahydrofuran; various solvent(s) / 1 h / 0 - 20 °C

With 1H-imidazole; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol049583y

Reference yield:

: 704906-80-9
{3-benzyloxy-4-[2-(tert-butyl-dimethyl-silanyloxy)-4-trimethylsilanyl-but-3-ynyl]-5-nitro-phenyl}-methanol

: 704906-88-7
[1-(2-benzyloxy-4-benzyloxymethyl-6-nitro-benzyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / potassium carbonate / methanol / 1.5 h / 20 °C

2: 96 percent / tetrabutylammonium iodide; sodium hydride / tetrahydrofuran; various solvent(s) / 1 h / 0 - 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1021/ol049583y