N-({3-[(4-Chloro-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Base Information

Chemical Name:N-({3-[(4-Chloro-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide
CAS No.:1240517-52-5
Molecular Formula:C₂₁H₁₈Cl₂N₄O₃S₂
Molecular Weight:509.437
Hs Code.:

Synonyms:N-({3-[(4-Chloro-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

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Chemical Property of N-({3-[(4-Chloro-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

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Technology Process of N-({3-[(4-Chloro-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

There total 5 articles about N-({3-[(4-Chloro-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1240518-78-8
N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide

: 64-19-7,77671-22-8
acetic acid

: 1240517-52-5
N-({3-[(4-Chloro-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1240518-78-8
N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide

: 108-24-7
acetic anhydride

: 1240517-52-5
N-({3-[(4-Chloro-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: N-(1-{[3-(aminomethyl)phenyl]methyl}-4-chloro-1H-indazol-3-yl)-5-chlorothiophene-2-sulfonamide; With triethylamine; In dichloromethane; at 20 ℃; for 0.333333h;

acetic anhydride; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm301572h

Reference yield:

: 20925-60-4
3-amino-4-chloro-1H-indazole

: 1240517-52-5
N-({3-[(4-Chloro-3-{[(5-chloro-2-thienyl)sulfonyl]amino}-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.42 h / 20 °C / Inert atmosphere

1.2: 2 h

2.1: pyridine / 0.5 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride; hydrogenchloride / diethyl ether; tetrahydrofuran / 45 h / 10 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.33 h / 20 °C

4.2: 2 h / 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; triethylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm301572h