2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide

Base Information

Chemical Name:2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide
CAS No.:1061358-64-2
Molecular Formula:C₁₃H₁₁ClF₃N₃O₂S
Molecular Weight:365.763
Hs Code.:

Synonyms:2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide

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Chemical Property of 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide

Chemical Property:

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Technology Process of 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide

There total 2 articles about 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16288-77-0
2-amino-N-methylbenzenesulfonamide

: 505084-55-9
2-chloro-4-iodo-5-(trifluoromethyl)pyridine

: 1061358-64-2
2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide

Guidance literature:: N-methyl-2-aminobenzenesulfonamide; 2-chloro-4-iodo-5-(trifluoromethyl)pyridine; With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 120 ℃; for 0.333333 - 0.5h; Microwave irradiation;

With trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1061358-64-2
2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.33 - 0.5 h / 120 °C / Microwave irradiation

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 2: Buchwald-Hartwig amination;

Reference yield:

: 13691-22-0
1-(4-aminophenyl)pyrrolidin-2-one

: 1061358-64-2
2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide

: 76-05-1
trifluoroacetic acid

: 1061353-80-7
N-methyl-2-(2-(4-(2-oxopyrrolidin-1-yl)-phenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)benzenesulfonamide trifluoroacetate

Guidance literature:: 1-(4-aminophenyl)pyrrolidin-2-one; 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide; With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 12 - 15h;

trifluoroacetic acid; In water; acetonitrile;