(5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:(5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester
CAS No.:71650-89-0
Molecular Formula:C₁₃H₁₉BrClNO₃Si
Molecular Weight:380.741
Hs Code.:

Synonyms:(5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of (5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

Chemical Property:

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Technology Process of (5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

There total 7 articles about (5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 71650-89-0
(5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / HNO₃, glacial acetic acid / acetic acid / 2 h / Ambient temperature

2: 88 percent / oxalyl chloride / dimethylformamide / -20 deg C; 80 deg C, 3 h

3: 30 g / KOH / ethanol; H₂O / 2 h / 80 °C

4: 60 percent / mercuric oxide, bromine / CCl₄ / 5 h / Irradiation

5: 1.) iron, 2.) HCl / 1.) ethanol, water, 2.) reflux, 12 h

6: 67 percent / aniline, pyridine / CH₂Cl₂ / 1.) 0 deg C, 10 min; 2.) room temperature, 1 h

7: t-BuOK / tetrahydrofuran / Ambient temperature

With pyridine; hydrogenchloride; potassium hydroxide; oxalyl dichloride; potassium tert-butylate; bromine; nitric acid; iron; acetic acid; aniline; mercury(II) oxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja00353a027

Reference yield:

: 63603-16-7
2-chloro-3-nitro-5-bromoanisole

: 71650-89-0
(5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) iron, 2.) HCl / 1.) ethanol, water, 2.) reflux, 12 h

2: 67 percent / aniline, pyridine / CH₂Cl₂ / 1.) 0 deg C, 10 min; 2.) room temperature, 1 h

3: t-BuOK / tetrahydrofuran / Ambient temperature

With pyridine; hydrogenchloride; potassium tert-butylate; iron; aniline; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00353a027

Reference yield:

: 63603-12-3
2-chloro-3-methoxy-5-bromoaniline

: 71650-89-0
(5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / aniline, pyridine / CH₂Cl₂ / 1.) 0 deg C, 10 min; 2.) room temperature, 1 h

2: t-BuOK / tetrahydrofuran / Ambient temperature

With pyridine; potassium tert-butylate; aniline; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00353a027