ethyl 10-(4-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5Hpyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

Base Information

Chemical Name:ethyl 10-(4-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5Hpyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate
CAS No.:1264932-12-8
Molecular Formula:C₂₄H₂₀N₂O₅
Molecular Weight:416.433
Hs Code.:

Synonyms:ethyl 10-(4-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5Hpyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

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Chemical Property of ethyl 10-(4-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5Hpyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

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Technology Process of ethyl 10-(4-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5Hpyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

There total 6 articles about ethyl 10-(4-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5Hpyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1081-17-0
N-(4-methoxyphenyl)maleimide

: 88014-09-9
(3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid ethyl ester

: 1264932-12-8
ethyl 10-(4-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5Hpyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

Guidance literature:: N-(4-methoxyphenyl)maleimide; (3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid ethyl ester; With tert.-butylhydroperoxide; Rh₂(cap)₄*2CH₃CN; potassium carbonate; In decane; acetonitrile;

With N-Bromosuccinimide; In decane; acetonitrile; for 1h;
DOI:10.1016/j.tetlet.2013.04.004

Reference yield: 83.0%

: 1264932-12-8
ethyl 10-(4-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5Hpyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

Guidance literature:: With oxygen; copper(I) bromide; In acetonitrile; at 60 ℃; for 10h;

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1264932-12-8
ethyl 10-(4-methoxyphenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5Hpyrrolo[3′,4′:3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.5 h / 20 °C

1.2: 0.5 h / 120 °C / Microwave irradiation

2.1: C₈₈H₃₀BF₂N₃; N-Bromosuccinimide / dichloromethane / 1 h / 20 °C / Irradiation

With N-Bromosuccinimide; C₈₈H₃₀BF₂N₃; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c3cc41494a