(4-((1-((3S,5S)-5-(bis(ethylthio)methyl)-1-(4-(5-(4-((4-((S)-2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrophenyl)((S)-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)methanone

Base Information

• Chemical Name: (4-((1-((3S,5S)-5-(bis(ethylthio)methyl)-1-(4-(5-(4-((4-((S)-2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrophenyl)((S)-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)methanone
• CAS No.: 1238824-62-8
• Molecular Formula: C₆₂H₈₄N₁₂O₁₅S₆
• Molecular Weight: 1429.82
• Mol file: 1238824-62-8.mol

Synonyms:(4-((1-((3S,5S)-5-(bis(ethylthio)methyl)-1-(4-(5-(4-((4-((S)-2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrophenyl)((S)-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)methanone

Chemical Property of (4-((1-((3S,5S)-5-(bis(ethylthio)methyl)-1-(4-(5-(4-((4-((S)-2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrophenyl)((S)-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-((1-((3S,5S)-5-(bis(ethylthio)methyl)-1-(4-(5-(4-((4-((S)-2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrophenyl)((S)-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)methanone

There total 1 articles about (4-((1-((3S,5S)-5-(bis(ethylthio)methyl)-1-(4-(5-(4-((4-((S)-2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrophenyl)((S)-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal (1037070-06-6) + ((2S,4S)-4-azido-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)(4-(5-azidopentyloxy)-5-methoxy-2-nitrophenyl)methanone (1238824-54-8) → (4-((1-((3S,5S)-5-(bis(ethylthio)methyl)-1-(4-(5-(4-((4-((S)-2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrophenyl)((S)-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)methanone (1238824-62-8)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; for 12h;

DOI:10.1016/j.tet.2010.05.003

Reference yield:

(4-((1-((3S,5S)-5-(bis(ethylthio)methyl)-1-(4-(5-(4-((4-((S)-2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrophenyl)((S)-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)methanone (1238824-62-8) → C62H90N12O9S6 (1238824-71-9)

Guidance literature:

(4-((1-((3S,5S)-5-(bis(ethylthio)methyl)-1-(4-(5-(4-((4-((S)-2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrophenyl)((S)-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)methanone; In methanol; at 25 ℃; for 0.166667h; Sonication;

With tin(II) chloride dihdyrate; In methanol; for 1h; Reflux;

DOI:10.1016/j.tet.2010.05.003

upstream raw materials:

(2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal

((2S,4S)-4-azido-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)(4-(5-azidopentyloxy)-5-methoxy-2-nitrophenyl)methanone

Downstream raw materials:

C₆₂H₉₀N₁₂O₉S₆