N-((phenoxy)((5-hydroxy-2-phenyl-4-oxo-4H-chromene-7-yl)oxy)phosphoryl)-L-leucine methyl ester

Base Information

Chemical Name:N-((phenoxy)((5-hydroxy-2-phenyl-4-oxo-4H-chromene-7-yl)oxy)phosphoryl)-L-leucine methyl ester
CAS No.:1240428-38-9
Molecular Formula:C₂₈H₂₈NO₈P
Molecular Weight:537.506
Hs Code.:

Synonyms:N-((phenoxy)((5-hydroxy-2-phenyl-4-oxo-4H-chromene-7-yl)oxy)phosphoryl)-L-leucine methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((phenoxy)((5-hydroxy-2-phenyl-4-oxo-4H-chromene-7-yl)oxy)phosphoryl)-L-leucine methyl ester

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Technology Process of N-((phenoxy)((5-hydroxy-2-phenyl-4-oxo-4H-chromene-7-yl)oxy)phosphoryl)-L-leucine methyl ester

There total 2 articles about N-((phenoxy)((5-hydroxy-2-phenyl-4-oxo-4H-chromene-7-yl)oxy)phosphoryl)-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.7%

: 480-40-0
5,7-dihydroxy-2-phenyl-chromen-4-one

: 147907-41-3
phenyl methoxyleucinyl phosphorochloridate

: 1240428-38-9
N-((phenoxy)((5-hydroxy-2-phenyl-4-oxo-4H-chromene-7-yl)oxy)phosphoryl)-L-leucine methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 6.5h;
DOI:10.1016/j.ejmech.2016.02.012

Reference yield:

: 770-12-7
O-phenyl phosphorodichloridate

: 1240428-38-9
N-((phenoxy)((5-hydroxy-2-phenyl-4-oxo-4H-chromene-7-yl)oxy)phosphoryl)-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / -70 - 20 °C

2: triethylamine / tetrahydrofuran / 6.5 h / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2016.02.012