3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid methyl ester

Base Information

Chemical Name:3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid methyl ester
CAS No.:797763-49-6
Molecular Formula:C₂₂H₂₅NO₃
Molecular Weight:351.445
Hs Code.:

Synonyms:3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid methyl ester

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Chemical Property of 3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of 3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid methyl ester

There total 9 articles about 3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 86-13-5,13050-78-7
benzatropine

: 797763-49-6
3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid methyl ester

Guidance literature:: With sodium carbonate; In 1,2-dichloro-ethane; at 85 ℃; for 3h;
DOI:10.1021/acschembio.8b00454

Reference yield: 83.0%

: 79-22-1
methyl chloroformate

: 3α-benzhydryloxy-8-azabicyclo[3.2.1]octane

: 797763-49-6
3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid methyl ester

Guidance literature:: With pyridine; at 20 ℃; for 0.5h;
DOI:10.1039/b405768f

Reference yield:

: 120-29-6
3-tropanol

: 797763-49-6
3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 1 h / Heating

1.2: MeOH / 0.75 h / Heating

2.1: 6.14 g / aq. NaHCO₃ / acetone

3.1: NaH / dimethylformamide / 1 h / 20 °C

3.2: 85 percent / dimethylformamide / 24 h / 25 °C

4.1: 73 percent / ICl; NaN₃ / acetonitrile; dimethylformamide / 70 h / Heating

5.1: 64 percent / toluene / 1 h

6.1: 94 percent / 2,6-lutidine; TMSOTf / CH₂Cl₂ / 0.75 h / 20 °C

7.1: 83 percent / pyridine / 0.5 h / 20 °C

With pyridine; 2,6-dimethylpyridine; sodium azide; carbonochloridic acid 1-chloro-ethyl ester; trimethylsilyl trifluoromethanesulfonate; Iodine monochloride; sodium hydride; sodium hydrogencarbonate; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1039/b405768f