3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
CAS No.:797763-48-5
Molecular Formula:C₂₅H₃₁NO₃
Molecular Weight:393.526
Hs Code.:

Synonyms:3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

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Chemical Property of 3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of 3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

There total 5 articles about 3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: phenylmagnesium bromide

: 797763-47-4
3α-(1-azidobenzyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

: 797763-48-5
3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Guidance literature:: In toluene; for 1h;
DOI:10.1039/b405768f

Reference yield:

: 538-09-0
nortropine

: 797763-48-5
3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 6.14 g / aq. NaHCO₃ / acetone

2.1: NaH / dimethylformamide / 1 h / 20 °C

2.2: 85 percent / dimethylformamide / 24 h / 25 °C

3.1: 73 percent / ICl; NaN₃ / acetonitrile; dimethylformamide / 70 h / Heating

4.1: 64 percent / toluene / 1 h

With sodium azide; Iodine monochloride; sodium hydride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1039/b405768f

Reference yield:

: 120-29-6
3-tropanol

: 797763-48-5
3α-benzhydryloxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 1 h / Heating

1.2: MeOH / 0.75 h / Heating

2.1: 6.14 g / aq. NaHCO₃ / acetone

3.1: NaH / dimethylformamide / 1 h / 20 °C

3.2: 85 percent / dimethylformamide / 24 h / 25 °C

4.1: 73 percent / ICl; NaN₃ / acetonitrile; dimethylformamide / 70 h / Heating

5.1: 64 percent / toluene / 1 h

With sodium azide; carbonochloridic acid 1-chloro-ethyl ester; Iodine monochloride; sodium hydride; sodium hydrogencarbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1039/b405768f